A Study Comparing Two Types of Radiation Therapy for Early-Stage Breast Cancer: Partial vs. Whole Breast Irradiation

Prospective Randomised Study Comparing Accelerated Partial Breast Irradiation with Whole Breast Irradiation By 3 Dimensional Conformal Radiotherapy In Patients With Early Stage Breast Cancer - NIL

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/078980

Enrollment

Registered

2025-01-20

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C509- Malignant neoplasm of breast of unspecified site

Interventions

Intervention1: Accelerated partial breast irradiation: One group will receive radiotherapy by accelerated partial breast irradiation with a dose of 22.5Gy at 7.5Gy per fraction over 3 days. Control In

Eligibility

Inclusion criteria

Inclusion criteria: 1. Tumor size T1-T2 2. Nodes negative 3. Non metastatic 4. Negative surgical margin 5. Unicenteric 6. Unifocal 7. Lymphovascular invasion absent 8. No neoadjuvant chemotherapy given

Exclusion criteria

Exclusion criteria: 1. Tumor size (T3,T4) 2. Positive nodes 3. Metastatic 4. Positive surgical margin 5. Multicentric 6. Multifocal 7. Lobular carcinoma in situ

Design outcomes

Primary

Measure	Time frame
Acute radiation toxicity after radiotherapy treatmentTimepoint: At 1 month, 2 months and 3 months after radiotherapy treatment	—

Secondary

Measure	Time frame
CosmesisTimepoint: At 3 months, 6 months and 9 months after radiotherapy treatment;Late toxicityTimepoint: At 6 months and 9 months after radiotherapy treatment;Quality of lifeTimepoint: At 3 months and 6 months after radiotherapy treatment	—

Countries

India

Contacts

Public ContactDr Monsu Rathod

Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh

drbudhi@gmail.com9815981176

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026