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to explore how Botox (botulinum toxin A) injections can help reduce the tightness and scarring that often happen after skin grafts or flap surgeries in people whose eyelids turn outward due to abnormal contraction

Evaluation of botulinum toxin A effect on skin graft and flap contracture in cicatricial ectropion - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/01/078979
Enrollment
24
Registered
2025-01-20
Start date
Unknown
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H021- Ectropion of eyelid

Interventions

Intervention1: Full thickness skin grafting + Botulinum Toxin A: 0.15ml per cm of length of skin graft, once administered via subcutaneously beneath the graft intra-operatively after securing the graf

Sponsors

Postgraduate Institute of Medical Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient presenting to oculoplastic clinic with cicatricial ectropion. 2. Patients with age more than 18 years. 3. Patients consenting for the use of BTX A. 4. Any grades of cicatricial ectropion severity.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
1. Calculating mean deviation of parameters like Lid Lag, Lid contour, lid laxity, lid position, graft contracture, blink character. 2. Graft width with surface area using standardised photographs 3.Calculating standard deviation of all parameters.Timepoint: day 2, 7, 14, 1 month, 6 weeks, 3 months—

Secondary

MeasureTime frame
Lid lag, Lid laxity, Blink characters, Corneal erosions and Conjunctival congestionTimepoint: 3 months—

Countries

India

Contacts

Public ContactDr Manu Saini

PGIMER

Manusaini1024@gmail.com9999249626

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026