Health Condition 1: M179- Osteoarthritis of knee, unspecified
Conditions
Interventions
Intervention1: polmacoxib: Oral Polmacoxib 2 mg once daily morning after food for 10 days
Control Intervention1: aceclofenac and Paracetamol combination: Oral Aceclofenac 100mg + Paracetamol 325mg twi
Sponsors
Dr Nagur Sharone Grace
Eligibility
Inclusion criteria
Inclusion criteria: Osteoarthritis involving unilateral or bilateral knees,Patients with radiographic osteoarthritic changes of grade 1 to 3 of Kellgren and Lawrence system of osteoarthritis classification, WOMAC Pain subscale score range of 5-15
Exclusion criteria
Exclusion criteria: History of Hypersensitivity to NSAIDS, Carbonic anhydrase inhibitors; Patients on corticosteroids, opioids, Selective Serotonin Reuptake Inhibitors, benzodiazepines, antipsychotics, anticoagulants, antiplatelets, Angiotensin Converting Enzyme Inhibitors, Angiotensin Receptor Blockers;Patients with medical history of peptic ulcer disease, GI bleeding, coagulant disorder, any cardiovascular disease; 6. Any medical condition or comorbidities, which in the clinician/investigator opinion could affect the safety and wellbeing of participants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the WOMAC-Pain Subscale between the groupsTimepoint: 10 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in the WOMAC OA index between, within the groups; Any ADRs with study drugs Timepoint: 10 days | — |
Countries
India
Contacts
Public ContactDr N Sharone Grace
Nizams Institute of Medical Sciences
Outcome results
None listed