Health Condition 1: C858- Other specified types of non-Hodgkin lymphoma
Conditions
Interventions
Intervention1: Observation: Patients will not go for Radiotherapy. They will keep doing follow up as scheduled six monthly for total duration of five years and yearly after that.
Control Intervention1
to be started within 6 weeks from last chemotherapy
Sponsors
Dr Sangeeta Kakoti
Eligibility
Inclusion criteria
Inclusion criteria: 1) Patients aged 18 years and above, with biopsy confirmed DLBCL (stage I-IV) and baseline bulky (more than 7 cm in maximum diameter) lymph node and/or extra-nodal sites of disease 2) Received 6 cycles of Immuno-chemotherapy (R-CHOP) 3) Complete metabolic response in interim or end-of-chemotherapy PET-CT scan
Exclusion criteria
Exclusion criteria: 1) Patients with relapsed/refractory DLBCL 2) Prior chemo/radiotherapy due to any other disease 3) Retro-positive patients 4) Patients with testicular/CNS lymphoma 5) Patients with background indolent NHL 6) Patients with disseminated extra-nodal sites, technically not feasible to be included in RT portal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare 2-year Event Free Survival (EFS)Timepoint: 2 years | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) To compare 2-year Local control (LC) 2) To compare 2-year Overall survival (OS) 3) To compare acute and late toxicities of patients with and without consolidative RTTimepoint: 2 years | — |
Countries
India
Contacts
Public ContactDr Sangeeta Kakoti
Department of Radiation Oncology, ACTREC, Tata Memorial Centre Mumbai
Outcome results
None listed