Health Condition 1: S040- Injury of optic nerve and pathways
Conditions
Interventions
Intervention1: Lamivudine: Oral tablet - 150mg twice daily for 2 months
This group will receive intravenous methyl prednisoloe 1 gram for 3 days followed by tapering doses of oral prednisolone along
Sponsors
Aravind Eye Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1)Patient age of 18 years or older 2)Clinical diagnosis of traumatic optic neuropathy within 2 weeks of injury. 3)Best corrected visual acuity (BCVA) between 20/40 and light perception in the affected eye. 4)Ability to provide informed consent.
Exclusion criteria
Exclusion criteria: 1)Pregnant patients, currently lactating patients, or females of childbearing potential (unless using reliable contraception such as double barrier, surgical sterilization, oral contraceptives, intrauterine device (IUD), etc. 2)Prior history of optic neuropathy or other ocular diseases. 3)Known hypersensitivity to Lamivudine or any component of the formulation. 4)Positive ELISA for HIV. 5)Abnormal liver function tests
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean change in Best corrected visual acuity (BCVA) from baseline to 8 weeks. Assessed with Early treatment diabetic retinopathy study (ETDRS) visual acuity testing chartTimepoint: baseline and week 1,2,4 and 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in color vision, visual field, contrast sensitivity, Visual Evoked potential, peripapillary retinal nerve fibre layer thickness and macular Ganglion cell complex thickness by Optical Coherence TomographyTimepoint: baseline and week 1,2,4 and 8 weeks | — |
Countries
India
Contacts
Public ContactDr Karthik Kumar M
Aravind Eye Hospital, Coimbatore
Outcome results
None listed