A study looked at whether Clonidine or Dexmedetomidine, when added to Ropivacaine, gives better pain relief for people having gallbladder surgery

Comparison of the efficacy of Clonidine and Dexmedetomidine as adjuvants to Ropivacaine in bilateral erector spinae plane block in patients undergoing laparoscopic cholecystectomy - A randomised controlled trial - Nil

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/078742

Enrollment

Registered

2024-12-30

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Erector spinae plane block: The ESP block will be performed pre-induction using a portable ultrasound device with a 6-13 MHz transducer. Patients will be positioned laterally, and sedo-

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective unilateral laparoscopic cholecystectomy surgery Agrees to participate in research Age 18 - 65 years BMI 25 - 35 kg/ m2

Exclusion criteria

Exclusion criteria: Patient refusal Failure to comprehend visual analogue scale Contraindications to intervention procedure (ESP block) History of local anaesthetic allergy Cardiovascular, respiratory, neurological or metabolic diseases, severe coagulopathy History of chronic analgesic use Failure of intervention procedures (ESP block) History of alcohol and substance addiction Known psychiatric disorders or use of psychiatric medications

Design outcomes

Primary

Measure	Time frame
clonidine and dexmedetomidine added as adjuvants to ropivacaine for ultrasound guided erector spinae plane block in laparoscopic cholecystectomy patients, prolong the duration of analgesia and improve patient comfort.Timepoint: 24 hours	—

Secondary

Measure	Time frame
Comparison of efficacy of clonidine and dexmedetomidine as adjuvants to 0.25% ropivacaine Total dose of fentanyl consumption in the postoperative period Comparison of intraoperative fentanyl required to suppress pain response Comparison of time to first rescue analgesia (use of PCA) Reduction in opioid related side effects such as nausea, vomiting, sedation Comparison of side effects related to adjuvants like hypotension, bradycardia and sedation Comparison of intraoperative hemodynamics between the groups Timepoint: 24 hours	—

Measure

Time frame

Comparison of efficacy of clonidine and dexmedetomidine as adjuvants to 0.25% ropivacaine Total dose of fentanyl consumption in the postoperative period Comparison of intraoperative fentanyl required to suppress pain response Comparison of time to first rescue analgesia (use of PCA) Reduction in opioid related side effects such as nausea, vomiting, sedation Comparison of side effects related to adjuvants like hypotension, bradycardia and sedation Comparison of intraoperative hemodynamics between the groups Timepoint: 24 hours

—

Countries

India

Contacts

Public ContactKondaveeti Anusha

Institute of liver and biliary sciences

tempedeepak@hotmail.com9718599401

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026