evaluating the effectiveness in reducing postoperative sore throat in laparoscopic gynaecological surgery under general anesthesia where one group of patients are given nebulization of dexmedetomidine and other group nebulization of dexamethasone.

comparison of the effectiveness of nebulized dexmedetomidine with nebulized dexamethasone in prevention of postoperative sore throat in patients undergoing laparoscopic gynaecological surgery under general anesthesia with endotracheal intubation - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/078727

Enrollment

160

Registered

2024-12-30

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N998- Other intraoperative and postprocedural complications and disorders of genitourinary system

Interventions

Intervention1: Dexmedetomidine: Dexmedetomidine nebulization at dose of 1 microgram per kg bodyweight and total volume of 4 ml is given to one group of patients 15 minutes before induction after patie

Eligibility

Inclusion criteria

Inclusion criteria: 1.patients scheduled for laparoscopic gynaecological surgery under genral anesthesia,planned for ontable extubation and expected to gain consciousness in 2 hours postoperatively 2.ASA physical status 1-2 3.age 18-60 years 4.patients with anticipated full recovery within 2 hrs postoperatively

Exclusion criteria

Exclusion criteria: 1.ASA Physical status more than or equal to 3 2.BMI morethan or equal to 30 kg/m-2 3.recent respiratory tract infection 4.chronic respiratory illness 5.history of maxillofacial and neck surgery 6.severe cardiopulmonary ,liver and kidney dysfunction 7.difficult airway 8.duration of surgery more than 3 hours 9.suspected or confirmed COVID 19 10.expected delayed extubation or no plan for extubation. 11.chronic use of opiods and sedatives 12.allergy to dexmedetomidine or dexamethasone 13.history of preoperative chemotherapy

Design outcomes

Primary

Measure	Time frame
to compare incidence of postoperative sore throat with nebulized dexmedetomidine and nebulized dexamethasone in patients undergoing laparoscopic gynaecological surgery under general anesthesia with endotracheal intubationTimepoint: 0,2,4,12,24 hours post extubation	—

Secondary

Measure	Time frame
to compare duration of sedation and perioperative hemodynamic parameters (HR,SBP,DBP,MAP,SPO2) with nebulized dexmedetomidine and nebulized dexamethasone in patients undergoing laparoscopic gynaecological surgery under general anesthesia with endotracheal intubationTimepoint: sedation-15 min,30min postextubation hemodynamic parameters(HR,SBP,DBP,MAP,SPO2)- Prenebulization,preinduction, every 5 min till 30 min post intubation,0,2,4,12,24 hrs post extubation	—

Measure

Time frame

to compare duration of sedation and perioperative hemodynamic parameters (HR,SBP,DBP,MAP,SPO2) with nebulized dexmedetomidine and nebulized dexamethasone in patients undergoing laparoscopic gynaecological surgery under general anesthesia with endotracheal intubationTimepoint: sedation-15 min,30min postextubation hemodynamic parameters(HR,SBP,DBP,MAP,SPO2)- Prenebulization,preinduction, every 5 min till 30 min post intubation,0,2,4,12,24 hrs post extubation

—

Countries

India

Contacts

Public ContactGarimella V K Dheeraja

Institute of medical sciences and SUM hospital

drranjitaacharya@gmail.com8763421899

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026