Health Condition 1: F20- Schizophrenia
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: Nil: Nil
Sponsors
Government Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Persons diagnosed with Schizophrenia as per ICD-10 2. On active treatment with anti-psychotics with minimum duration of at least 6 months 3. Any gender 4. Age 18 to 50 years 5. Having capacity to give consent / Nominated Representative giving consent 6. Participants who are willing to get the investigations (DEXA scan, hormone studies, routine investigations) done for the study after informed consent
Exclusion criteria
Exclusion criteria: 1. Substance abuse or dependence except nicotine and caffeine 2. Psychiatric illness like eating disorders 3. Patient currently pregnant or lactating 4. Known cases of Bone metabolism diseases, electrolyte imbalance, renal function impairment, pituitary tumor, parathyroid diseases, hyperthyroidism, metabolic bone disorders, bone tumors, Paget’s disease and osteogenesis imperfecta. 5. Co-medications known to affect Bone Mineral Density (e.g. drugs for osteoporosis treatment such as alendronate, parathyroid hormone, estrogens, selective estrogen receptor modulators, bisphosphonates, and calcitonin, heparin, and glucocorticoids).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Association between Schizophrenia and BMD based upon the type and number of drug i.e. (i.) FGA vs SGA (First generation antipsychotics vs Second generation antipsychotics); (ii.) Prolactin Sparing vs Prolactin raising APD; (iii.) Single APD vs multiple APDs and Duration of illness and on treatment for a) Less than 2 years b) 2 years to 9 years c) More than 10 yearsTimepoint: At baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Association of BMD & endocrine & metabolic parameters 2.Evaluation of BMD in relation to severity of illness, quality of life, physical activity 3. Association of BMD between quality of life & disability with positive & negative symptoms of schizophrenia. 4.Association of BMD with bone health promoting nutraceuticals in the form of vitamin D & Calcium supplementation in past 6 monthsTimepoint: At baseline | — |
Countries
India
Contacts
Public ContactDr Ajeet Sidana
Government Medical College and Hospital, Sector 32, Chandigarh
Outcome results
None listed