A clinical trial to compare the effect of airway nebulisation with lignocaine and dexmedetomidine on hemodynamic stress response to laryngoscopy and intubation in general endotracheal anaesthesia

Comparison of effect of airway nebulization with lignocaine and dexmedetomidine on hemodynamic stress response to laryngoscopy and intubation in patients undergoing elective surgery under general endotracheal anaesthesia – A prospective randomized double blind study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/078705

Enrollment

Registered

2024-12-30

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine nebulisation: nebulized with Dexmedetomidine 1mcg/kg Twenty minutes prior to induction of anesthesia. Control Intervention1: lignocaine nebulisation: nebulized with lign

Eligibility

Inclusion criteria

Inclusion criteria: patient aged 18 to 65 years American society of anaesthesiologist status I and II patient scheduled to undergo surgery of less than 3 hours who require endotracheal intubation

Exclusion criteria

Exclusion criteria: 1.Patients not willing to give consent. 2.BMI greater than 30 kg/m2 3.Pregnant and lactating women 4.Patients with known allergy to study drugs. 5.Patients with uncontrolled systemic diseases 6.Anticipated difficult intubation 7.Laryngoscopy more than 20 seconds and more than 1 attempt at intubation are excluded retrospectively 8.Patients having a history of preoperative sore throat or recent upper respiratory tract infection.

Design outcomes

Primary

Measure	Time frame
To study and compare the hemodynamic stress response Heart rate(HR), systolic blood pressure(SBP), diastolic blood pressure (DBP)and mean arterial pressure(MAP) to laryngoscopy and intubation between 4% lignocaine group and Dexmedetomidine groupTimepoint: at baseline (T0), after induction(T1), immediately after intubation(T2), at 1 min(T3), 2 min(T4), 3min(T5) and 5min(T6) after intubation.	—

Secondary

Measure	Time frame
1.To study the incidence of post operative sedation score using Ramsay sedation score (RSS). 2.To study the incidence of post operative sore throat or cough at 0, 6, 12, 24 hrs after tracheal extubation 3.To study the incidence of post op hoarseness of voice at 0, 6, 12, 24 hrs after tracheal extubation Timepoint: 1. Ramsay sedation score at 15,30, 60,90,120,150 minutes after extubation 2.incidence of post operative sore throat or cough at 0, 6, 12, 24 hrs after tracheal extubation incidence of post op hoarseness of voice at 0, 6, 12, 24 hrs after tracheal extubation	—

Measure

Time frame

1.To study the incidence of post operative sedation score using Ramsay sedation score (RSS). 2.To study the incidence of post operative sore throat or cough at 0, 6, 12, 24 hrs after tracheal extubation 3.To study the incidence of post op hoarseness of voice at 0, 6, 12, 24 hrs after tracheal extubation Timepoint: 1. Ramsay sedation score at 15,30, 60,90,120,150 minutes after extubation 2.incidence of post operative sore throat or cough at 0, 6, 12, 24 hrs after tracheal extubation incidence of post op hoarseness of voice at 0, 6, 12, 24 hrs after tracheal extubation

—

Countries

India

Contacts

Public ContactDr Peyyety Janaki Subhadra

Sri venkateswara institute of medical sciences

subhadrapeyyety@gmail.com9493547655

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026