A study checked how two anesthesia drugs, Desflurane and Propofol, affect liver healing and damage from blood flow changes during liver transplant surgery.

Comparison of the effect of Desflurane versus total intravenous anesthesia with Propofol on ischemia reperfusion injury and liver regeneration in liver transplant recipients - A randomised controlled trial - Nil

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/078700

Enrollment

Registered

2024-12-27

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: K721- Chronic hepatic failure

Interventions

Intervention1: General anaesthesia: Propofol total intravenous anaesthesia with BIS maintained between 40-60 range, and Inhalationl anaesthesia with Desflurane with MAC 0.8-1.2 range are compared. Tot

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective living donor liver transplantation for chronic liver disease Agrees to participate in research Age 18-65 years

Exclusion criteria

Exclusion criteria: Refusal to consent Acute liver failure, Acute on chronic liver failure Allergic to propofol or any component of propofol Patients with pre existing cardiac dysfunction and cardiomyopathy Patients with pre existing renal dysfunction/ deranged RFTs preoperatively

Design outcomes

Primary

Measure	Time frame
Desflurane is comparable to TIVA with Propofol in preventing hepatocyte ischemia-reperfusion injury and promoting hepatic regeneration. Timepoint: 14 days	—

Secondary

Measure	Time frame
To compare the serum levels of liver regeneration markers [hepatocyte growth factor(HGF), Vascular enndothelial growth factor(VEGF)] during baseline, POD 1 and 7 Comparison of the incidence of ischemia reperfusion injury using the serum levels of markers CK 8/18, VWF, IL-6, IL-1ß, TNF-a, HMGB-1, mtDNA, LDH, lactic acid during baseline, immediate post-reperfusion(30min-1hr), early post-reperfusion(6h-12h), early postoperative period(24h-48h). To compare the incidence and severity of post reperfusion syndrome To compare the liver function tests (Sr. Bilirubin, AST, ALT, GGT, albumin, platelet count, prothrombin time, INR, lactate) during baseline, POD 1 to 7 Timepoint: 7 days	—

Measure

Time frame

To compare the serum levels of liver regeneration markers [hepatocyte growth factor(HGF), Vascular enndothelial growth factor(VEGF)] during baseline, POD 1 and 7 Comparison of the incidence of ischemia reperfusion injury using the serum levels of markers CK 8/18, VWF, IL-6, IL-1ß, TNF-a, HMGB-1, mtDNA, LDH, lactic acid during baseline, immediate post-reperfusion(30min-1hr), early post-reperfusion(6h-12h), early postoperative period(24h-48h). To compare the incidence and severity of post reperfusion syndrome To compare the liver function tests (Sr. Bilirubin, AST, ALT, GGT, albumin, platelet count, prothrombin time, INR, lactate) during baseline, POD 1 to 7 Timepoint: 7 days

—

Countries

India

Contacts

Public ContactKondaveeti Anusha

Institute of liver and biliary sciences

drsindwani25@gmail.com8728089898

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026