Health Condition 1: C719- Malignant neoplasm of brain, unspecified
Conditions
Interventions
Intervention1: Remifentanil Infusion: Patients allocated to this group will receive Remifentanil TCI infusion based on body weight, height, age and sex, to meet a target plasma concentration of 6-8 ng
Sponsors
Institute of Neurosciences Kolkata
Eligibility
Inclusion criteria
Inclusion criteria: ASA grade I, II, III Either gender BMI less than35 kg/m2 Any craniotomy for both supra-tentorial & infra-tentorial space occupying lesion GCS of 15/15 Duration of surgery of 4 hr
Exclusion criteria
Exclusion criteria: Patient refusal body mass index more than 35 kg/m2, GCS less than 15/15 H/o previous craniotomy If rapid postoperative return to normal consciousness was unlikely, owing to the location or size of lesion or postoperative ventilation is planned uncontrolled hypertension/ significant CAD/ cardiac conduction block/ severe renal dysfunction/ CLD/ chronic obstructive pulmonary disease (GOLD 3/4) / neuropsychiatric disorders chronic pain requiring opioid analgesia, reported allergy to either study drug, patients having awake craniotomies or craniotomies requiring intraoperative CT/ magnetic resonance scanning (because the length of surgery will be much longer).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ease of extubation: 1.Time to eye opening 2.Time to extubation 3.Cough 4.Sedation 5.PainTimepoint: During extubation ( 0 min) | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rateTimepoint: At induction of anesthesia, head pinning, incision, during burring, 30 min, 1 hr,2 hr, 3 hr, 4 hr;Systolic blood pressureTimepoint: At induction of anesthesia, head pinning, incision, during burring, 30 min, 1 hr,2 hr, 3 hr, 4 hr;Diastolic blood pressureTimepoint: At induction of anesthesia, head pinning, incision, during burring, 30 min, 1 hr,2 hr, 3 hr, 4 hr;Mean arterial blood pressureTimepoint: At induction of anesthesia, head pinning, incision, during burring, 30 min, 1 hr,2 hr, 3 hr, 4 hr | — |
Countries
India
Contacts
Public ContactDr Eesha Banerjee
Institute of Neurosciences Kolkata
Outcome results
None listed