Effect of magnesium supplementation in increasing lactate removal in severe sepsis patients compared to control

EFFECT OF MAGNESIUM SUPPLEMENTATION ON LACTATE CLEARANCE IN CRITICALLY ILL PATIENTS WITH SEVERE SEPSIS VS CONTROL: A RANDOMIZED CONTROL CLINICAL TRIAL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/078671

Enrollment

Registered

2024-12-27

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium Sulphate: 2 grams of magnesium sulphate is given in 100 mL normal saline and 12 hourly magnesium levels are measured for first 3 days Control Intervention1: Normal saline: 100

Eligibility

Inclusion criteria

Inclusion criteria: Patients admitted with septic shock.

Exclusion criteria

Exclusion criteria: Severe cardiac diseases CKD on maintainence hemodialysis Liver diseases [child pugh B & C] Malignancy Pregnancy Hypo/hypermagnesemia HYPERKALEMIA

Design outcomes

Primary

Measure	Time frame
To determine any increase in lactate clearance following magnesium supplementation in critically ill septic patients from admission to day 3Timepoint: To determine any increase in lactate clearance following magnesium supplementation in critically ill septic patients from the time of admission to day 3	—

Secondary

Measure	Time frame
mortality in ICU length of ICU stayTimepoint: length of ICU stay	—

Countries

India

Contacts

Public ContactDr Amarnath Kadagud

KEM hospital Pune

evileye.amar@gmail.com9686774935

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026