Health Condition 1: C419- Malignant neoplasm of bone and articular cartilage, unspecified
Conditions
Interventions
Intervention1: Nil: NA
Control Intervention1: Nil: NA
Sponsors
Mahamana Pandit Madan Mohan Malaviya Cancer Centre and Homi Bhabha Cancer Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Histopathologically confirmed Ewing’s sarcoma patient. 2. Non-Metastatic Ewing’s sarcoma patient except lung metastasis 3. Patients with Age more than 1 years or less than 80 years. 4. ECOG performance status 0-2 5. Patient with curative intent. 6. Patients with lung only metastasis or oligo metastatic disease with complete metabolic response post NACT and treated with curative intent chemoradiotherapy will also be included.
Exclusion criteria
Exclusion criteria: 1. Patients default during RT. 2. Histopathology other than Ewing’s Sarcoma. 3. Any patient not fitting into lung only or oligometastatic status. 4. Oligo metastatic disease without complete metabolic response post NACT in metastasis site will be excluded. 5. Patients who are planned for palliative dose of RT
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To correlate pre and post NACT tumor volume, extent of necrosis post NACT, pathological complete response, type of RT i.e. radical/ adjuvant and with PFS and OS of Ewing Sarcoma.Timepoint: at 1 year post treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of pre and post NACT PET CT SUVmax and metabolic factors with PFS and OS. Other patient related factors like age, sex, site and treatment related factors like RT dose, fractionation, lung bath etc will be correlated with short term outcomes.Timepoint: 18 months | — |
Countries
India
Contacts
Public ContactDr Ashutosh Mukherji
Mahamana Pandit Madan Mohan Malaviya Cancer Centre and Homi Bhabha Cancer Hospital
Outcome results
None listed