Health Condition 1: F332- Major depressive disorder, recurrent severe without psychotic features
Conditions
Interventions
Intervention1: SSRIs plus Pramipexole: (0.375mg/day starting dose and maximaly titrated ot 4.5mg/day based on tolerability and clinical assessments over 8 weeks
Control Intervention1: SSRI + placebo:
Sponsors
Dr Vincent Soram
Eligibility
Inclusion criteria
Inclusion criteria: Major depressive disorder as diagnosed by DSM-5 criteria Presence of clinically assessed motivational deficits, psychomotor retardation and anhedonia score less than 30 on Dimensional Anhedonia Rating Scale
Exclusion criteria
Exclusion criteria: Comorbid psychotic spectrum, bipolar or severe personality disorders Concurrent dopamine antagonists or agonist therapy Current substance withdrawal or intoxicated states Pregnancy, lactation or inadequate contraception among women Parkinsons disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease in the score of Montgomery–Åsberg Depression Rating Scale over 4 weeksTimepoint: Decrease in the score of Montgomery–Åsberg Depression Rating Scale over 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in score of Clinical Global Impression Scale over 4 weeks.Timepoint: Change in score of Clinical Global Impression Scale over 4 weeks.;Change in score of Dimensional Anhedonia rating scale over 4 weeks Timepoint: Change in score of Dimensional Anhedonia rating scale over 4 weeks | — |
Countries
India
Contacts
Public ContactDr Vincent Soram
Kalinga Institute of Medical Sciences
Outcome results
None listed