Effectiveness of Topical Tranexamic Acid in Decreasing During Operation And After Operation Bleeding After Nasal Surgery

Effectiveness of Topical Tranexamic Acid in Reducing Intraoperative and Postoperative Bleeding Following Nasal Endoscopic Sinus Surgery: Randomized Controlled Trial - NIL

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2024/12/078600

Enrollment

Registered

2024-12-26

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 3- Administration

Interventions

Intervention1: Tranexamic Acid: It is going to be used in pre operative and post operative nasal packing i.e topically post endoscopic sinus surgeries as compared to saline in the control group Contr

Eligibility

Inclusion criteria

Inclusion criteria: Adults of 18 years and above requiring endoscopic sinus surgery. . Patients aged 18 and above attending ENT OPD in AVMC with conditions such as chronic rhinosinusitis with or without polyp , Antrochoanal polyp, nasal diseases requiring unilateral or bilateral endoscopic sinus surgery scheduled for nasal endoscopic sinus surgery.

Exclusion criteria

Exclusion criteria: Known allergy to tranexamic acid. 2. History of thromboembolic events, Coagulopathy, or use of anticoagulant medications. 3. Significant medical comorbidities (e.g., cardiovascular diseases, renal Impairment, with uncontrolled Diabetes and Hypertension). 4. Patients being operated for nasal tumour 5. Revision endoscopic nasal surgery

Design outcomes

Primary

Measure	Time frame
1.To assess the effectiveness of topical tranexamic acid in reducing intraoperative bleeding and immediate post op bleeding in patients undergoing endoscopic sinus surgery. 2.To assess the intra operative surgical field using Boezarts scale in both TXA group and control group in Endoscopic Sinus Surgery. Timepoint: Intra operative checked at 5 mins 15 mins 25 mins 35 mins post operatively checked at Immediate post operatively 6hrs post operatively 12 hrs post operatively 24 hrs post operatively	—

Measure

Time frame

1.To assess the effectiveness of topical tranexamic acid in reducing intraoperative bleeding and immediate post op bleeding in patients undergoing endoscopic sinus surgery. 2.To assess the intra operative surgical field using Boezarts scale in both TXA group and control group in Endoscopic Sinus Surgery. Timepoint: Intra operative checked at 5 mins 15 mins 25 mins 35 mins post operatively checked at Immediate post operatively 6hrs post operatively 12 hrs post operatively 24 hrs post operatively

—

Secondary

Measure	Time frame
1. To detect the duration of surgery in both the groupsTimepoint: 1. To detect the duration of surgery in both the groups ( noting time from start of surgery to the end )	—

Countries

India

Contacts

Public ContactBhairavi Sharma

Aarupadai Veedu Medical College and Hospital

drtcvikram@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026