Cerebral oxygenation during live donor liver transplant surgery and its effect on post operative cognitive dysfunction

Near infra red spectroscopy (NIRS) targeted goal directed therapy for intra operative hemodynamics & its impact on post operative neurological complications in Living donor liver transplant recipients A randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/078594

Enrollment

Registered

2024-12-26

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K721- Chronic hepatic failure

Interventions

Intervention1: PRBC transfusion based on NIRS: In one group NIRS monitoring will be done and if NIRS falls more than 20% of baseline , MAP will be increased up to 80, and PRBC will be transfused if lo

Eligibility

Inclusion criteria

Inclusion criteria: All patients between 18 to 65 years old undergoing living donor liver transplant

Exclusion criteria

Exclusion criteria: Patients with acute liver failure Patients with neurological disorders Patients with pre operative AKI

Design outcomes

Primary

Measure	Time frame
Comparison of incidence of post operative cognitive dysfunction between NIRS based goal directed therapy and non goal directed therapy group.Timepoint: Post operative day 7 and post operative day 28	—

Secondary

Measure	Time frame
Comparison of incidence of AKI in both groupsTimepoint: Post op day 7 and day 28	—

Countries

India

Contacts

Public ContactDr Gaurav Sindwani

Institute of liver and biliary science New Delhi

nidhisingh961991@gmail.com8358052071

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026