Study to compare 2 percent tofacitinib cream and calcipotriol 0.005 percent ointment in patchy hair loss over scalp

A comparative study on clinical efficacy of Topical Tofacitinib 2 percent cream versus Topical Calcipotriol 0.005 percent ointment in the treatment of Alopecia Areata - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2024/12/078575

Enrollment

100

Registered

2024-12-24

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L639- Alopecia areata, unspecified

Interventions

Intervention1: TOFACITINIB 2% CREAM: Tofacitinib Dose-2% Frequency-Twice Daily Route- Topical application over the affected area Follow up- 4weeks, 8weeks,12weeks, 16weeks Duration of study- 16weeks

Eligibility

Inclusion criteria

Inclusion criteria: All consenting patients of alopecia areata with SALT score less than 25% scalp involvement of either gender aged 18 years and above visiting in Dermatology OPD

Exclusion criteria

Exclusion criteria: Patients who have taken any form of treatment in past 3 months Immunocompromised patients or patients on immunosuppressive therapy will be excluded Pregnant or lactating mothers Patient with a history of hypersensitivity to tofacitinib or calcipotriol

Design outcomes

Primary

Measure	Time frame
To assess and compare the efficacy of topical tofacitinib cream (2%) and topical calcipotriol ointment (0.005%) in promoting hair regrowth and minimizing disease progression in individuals with alopecia areataTimepoint: 4 weeks,8 weeks,12 weeks, 16 weeks	—

Secondary

Measure	Time frame
To analyse the efficacy of tofacitinib cream (2%) in alopecia areata. To analyse the efficacy of calcipotriol ointment (0.005%) in alopecia areata. To analyse potential side effects & patientâ??s tolerability associated with the use of topical tofacitinib cream (2%) & topical calcipotriol ointment (0.005%).Timepoint: 4 weeks,8weeks,12weeks,16weeks	—

Countries

India

Contacts

Public ContactDR NEHA KHAN

Eraâ??s Lucknow Medical College and Hospital

drkshitijsaxena@live.com9208015391

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026