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Effect of buffered articaine on success of pulpal anesthesia in irreversible pulpits of molars

Buffered 4% articaine for improving success of pulpal anesthesia during endodontic therapy of mandibular molars affected by symptomatic irreversible pulpitis. A triple blind randomized parallel arm clinical study - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/12/078564
Enrollment
60
Registered
2024-12-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: 4%buffered articaine local anaesthetic solution: 1.7 mL of 4% articaine buffered with 8.4 % sodium bicarbonate solution to be used as local anesthesia Control Intervention1: 4% articain

Sponsors

DR SHAHNAZ
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Healthy patients having a first or second mandibular molar tooth with symptomatic irreversible pulpitis and normal periapical radiographic appearance. The clinical diagnosis of symptomatic irreversible pulpitis will be confirmed by a response to an electric pulp and a prolonged exaggerated response (10 seconds) with moderate to severe pain to a cold test. Sixty patients eligible to participate study will be included

Exclusion criteria

Exclusion criteria: Presence of systemic disorders, a sensitivity to articaine with 1:100,000 epinephrine or to Non-steroidal anti-inflammatory drugs, nasal polyp, a history of gastrointestinal ulcers, lactation, pregnancy, using any type of analgesic medication in the preceding 12 hours before the treatment, having a tooth not suitable for restoration, and having a full crown.

Design outcomes

Primary

MeasureTime frame
success of pulpal anesthesia after inferior alveolar nerve block with 1.7 mL 4% buffered articaineTimepoint: 15 min after anesthesia

Secondary

MeasureTime frame
Pain scores during access cavity preparatory mandibles molars with irreversible pulpitisTimepoint: After local anesthesia, at access cavity preparation and instrumentation

Countries

India

Contacts

Public ContactDr Shahnaz

Faculty of dentistry Jamia Millia Islamia

shahnaz@jmi.ac.in7006577811

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026