A comparative study to evaluate analgesic effect of injection dexamethasone as an adjuvant with local anesthetic drug bupivacaine and bupivacaine alone in ultrasound guided sphenopalatine ganglion block during and after surgery in patients undergoing head and neck cancer surgery

A comparative randomized study to evaluate analgesic effect of dexamethasone as an adjuvant with bupivacaine and bupivacaine alone in ultrasound guided supra-zygomatic sphenopalatine ganglion block perioperatively in patients undergoing elective head and neck cancer surgery - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/078429

Enrollment

Registered

2024-12-23

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C021- Malignant neoplasm of border of tongue

Interventions

Intervention1: Unilateral ultrasound guided sphenopalatine ganglion block through suprazygomatic approach: USG images will be obtained with a high-frequency (5-13MHz) linear array probe. The needle wi

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I-II patients, Aged 18–65 years, Patients scheduled for elective head and neck cancer surgery (involving dissection in area of maxilla, palate, retromolar trigone, anterior part of tongue, buccal mucosa) under general anaesthesia.

Exclusion criteria

Exclusion criteria: Patient refusal to participate, Patients who are allergic to local anaesthetics, Patient who require awake fibreoptic intubation, Patients with disfigurement and disturbed anatomy prevented easy access to the sphenopalatine ganglion, Patient who require PMMC flap and or free flap in their management, Those patient who require mechanical ventilation in postoperative stay, Those patients who will be tracheostomized during peri-operative period, History of bleeding disorders, or receiving anticoagulant therapy were excluded, Patients with a history of hepatic, renal, or cardiopulmonary dysfunction

Design outcomes

Primary

Measure	Time frame
To record the time required by the patient for first rescue analgesia i.e. 75mg diclofenac iv in PACUTimepoint: At PACU at 30min, 1h, 2h, 6h, 10h, 14h, 18h, 24h and 48 hours after surgery	—

Secondary

Measure	Time frame
Assessment of intraoperative hemodynamic parameters( HR, MAP, SpO2) at 30 min after induction till extubation of patient 2. Assessment of total perioperative opioid consumption 3. Assessment of postoperative VAS score followed by rescue analgesia consumption at 30min, 1h, 2h, 6h, 10h, 14h, 18h, 24h and 48 hours 4. Assessment SPGB complications like postoperative nausea and vomiting(PONV), visual disturbances, hypoesthesia of root of nose, pharynx, & palate, lacrimation of ipsilateral eye, retro-orbital heamotoma etc.Timepoint: 30min, 1h, 2h, 6h, 10h, 14h, 18h, 24h and 48 hours after surgery at PACU	—

Measure

Time frame

Assessment of intraoperative hemodynamic parameters( HR, MAP, SpO2) at 30 min after induction till extubation of patient 2. Assessment of total perioperative opioid consumption 3. Assessment of postoperative VAS score followed by rescue analgesia consumption at 30min, 1h, 2h, 6h, 10h, 14h, 18h, 24h and 48 hours 4. Assessment SPGB complications like postoperative nausea and vomiting(PONV), visual disturbances, hypoesthesia of root of nose, pharynx, & palate, lacrimation of ipsilateral eye, retro-orbital heamotoma etc.Timepoint: 30min, 1h, 2h, 6h, 10h, 14h, 18h, 24h and 48 hours after surgery at PACU

—

Countries

India

Contacts

Public ContactArchana Gautam

Department of Anesthesia Kalyan Singh Super Speciality Cancer Institute

archana.dolly76@gmail.com09936343627

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026