Health Condition 1: - Health Condition 2: E200- Idiopathic hypoparathyroidism
Conditions
Interventions
Intervention1: Sevelamer-hydrochloride along with on-going conventional therapy i.e, alphacalcidol and oral calcium: Patients with Idiopathic Hypoparathyroidism will be randomized into two arms: 1) Se
Sponsors
Indian Council of Medical Research-ICMR
Eligibility
Inclusion criteria
Inclusion criteria: Patients with idiopathic hypoparathyroidism with optimal calcium control i.e, serum total calcium value between 8.0-9.5 mg/dl on conventional therapy and have hyperphosphatemia i.e serum phosphate at least 5.0 mg/dl on last three visits during past one-year of follow-up will be considered eligible for the study.
Exclusion criteria
Exclusion criteria: 1. Patients with idiopathic hypoparathyroidism younger than 18 years or more than 75 years 2. pregnant, lactating, on steroid therapy for any reason, or have serious coexisting medical illness 3. Patients who will be unable to come for repeat follow-up at frequent interval (total 10 visits during study period of 10 months) will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of serum-phosphate by 0.5 mg/dL and normalisation of hyperphosphatemia will be an expected outcome.Timepoint: After 4 months of sevelamer hydrochloride therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in 24 hour urinary phosphate excretion & Fractional excretion of phosphorus (FEPh) after 4 months of sevelamer hydrochloride therapyTimepoint: After 4 months of sevelamer hydrochloride therapy | — |
Countries
India
Contacts
Public ContactRavinder Goswami
All India Institute of Sciences
Outcome results
None listed