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Does use of intra-uterine purified HCG hormone injection has any effect on Pregnancy outcome

Effect of Intra-uterine flushing of human chorionic gonadotropin before Intra-uterine Insemination (IUI) in Infertile females: A double-blinded Randomized control trial - NIL

Status
Recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/12/078379
Enrollment
150
Registered
2024-12-20
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N979- Female infertility, unspecified

Interventions

Intervention1: Intra-uterine HCG instillation at the time of IUI: Women undergoing natural cycle monitoring or Ovulation induction will be study population. Ovulation trigger will be given with 5000 I

Sponsors

Dr Srishty Choudhary
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Participants must meet all of the following criteria: Adequate ovarian reserve: Anti-Müllerian Hormone (AMH) level greater than 1.2 ng/mL. Antral Follicle Count (AFC) greater than 5 follicles. Age less than 35 years. Bilateral patent fallopian tubes confirmed through imaging. Partner’s Total Motile Sperm Count (TMSC) greater than 10 million.

Exclusion criteria

Exclusion criteria: Participants will be excluded if they meet any of the following conditions: Uncontrolled Chronic Disease: Including diabetes, hypertension, or thyroid dysfunction. Hydrosalpinx: Presence of fluid-filled, dilated fallopian tubes. Endometriosis: Moderate to severe endometriosis (Stage III or IV). Uterine Abnormalities: Submucosal fibroid or polyp of any size. Intramural fibroid greater than 4–5 cm in size. Endometrial Thickness: Thin endometrium less than 7 mm.

Design outcomes

Primary

MeasureTime frame
clinical pregnancy rateTimepoint: 7 weeks

Secondary

MeasureTime frame
biochemical pregnancy rateTimepoint: 14 days post IUI;miscarriage rateTimepoint: 12 weeks;ongoing pregnancy rateTimepoint: 12 weeks

Countries

India

Contacts

Public ContactDr Srishty Choudhary

Department of Reproductive Medicine and Surgery MGMC&H Jaipur

sangi237@yahoo.com9210921790

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026