None listed
Conditions
Interventions
Intervention1: NIL: NIL
Control Intervention1: NIL: NIL
Sponsors
St Johns Medical College Bangalore
Eligibility
Inclusion criteria
Inclusion criteria: Apparently healthy adults of both sexes
Exclusion criteria
Exclusion criteria: 1. Subjects who are on B12 supplements. 2. Antibiotic use in the last 3 months. 3. Diarrhea in the last 3 months. 4. on special/fad diets. 5 History of gastrointestinal surgery ( bowel resection, gastrectomy, vagotomy, ileostomy, bariatric, colostomy) 6. Uncontrolled co-morbidities like diabetes hypertension and cardiovascular disease, or this with history of allergic or hypersensitive reaction, were excluded from the study. 7. Clinical suspicion of any of the vitamin B deficiencies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine whether colonic microbiota can synthesize vitamins for human host absorption by providing 13C labeled cellulose as substrateTimepoint: The study is over a course of 72 hours with sampling at baseline, 24, 30, 36, 42, 48, 60, 72 hours. Sampling before 24 hours may be done after analysis of pilot data. | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine whether colonic microbiota can synthesize vitamins for human host absorption by providing 13C labeled cellulose as substrate to evaluate the association of measured microbial B12 levels in human blood with B12 status to identify specific bacterial strains in the microbe which are capable of measured vitamin productionTimepoint: The study is over a course of 72 hours with sampling at baseline, 24, 30, 36, 42, 48, 60, 72 hours. Sampling before 24 hours may be done after analysis pilot data. | — |
Countries
India
Contacts
Public ContactShalini Gajanan Hegde
St. John’s Research Institute
Outcome results
None listed