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To find the effective amount of medicine required in fluid around spinalcord for pain relief after open heart surgery through middle of chest wall

DETERMINATION OF ED90 OF INTRATHECAL MORPHINE FOR POST OPERATIVE ANALGESIA IN ADULT OPEN HEART SURGERY VIA STERNOTOMY USING A SEQUENTIAL ALLOCATION BIASED COIN METHOD. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/12/078206
Enrollment
40
Registered
2024-12-17
Start date
Unknown
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I050- Rheumatic mitral stenosis Health Condition 2: I080- Rheumatic disorders of both mitraland aortic valves

Interventions

Intervention1: Particular one dose of Intrathecal Opiod Morphine: Morphine in intrathecal space for cardiac surgery. First case dose was recruited with the lowest dose 4 micrograms per kg, available f

Sponsors

Division of cardiac anaesthesia, advanced cardiac centre.
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18-60 years ASA- II or III Posted for elective open heart surgery via midline sternotomy.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
To identify the lowest dose of intrathecal morphine that provided effective analgesia in 90% (ED90) of patients after elective adult single valve cardiac surgeryTimepoint: 48hrs from intrathecal morphine—

Secondary

MeasureTime frame
Time to first rescue analgesia Total opioid consumption at 6, 12, 24 and 48hrs RASS Duration of mechanical ventilation Incidence of post operative respiratory depression, pruritus, sedation, PONV. Time of spinal puncture to heparinization and incidence of spinal hematoma. Overall satisfaction score at 48 hours with spinal morphine Timepoint: 48hrs from intrathecal morphine—

Countries

India

Contacts

Public ContactSangamala Venkata Prem Kumar

Post Graduate Istitute of Medical Education and Research

driradhawan14@gmail.com9646036936

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026