Health Condition 1: C719- Malignant neoplasm of brain, unspecified Health Condition 2: G968- Other specified disorders of central nervous system
Conditions
Interventions
Intervention1: Hypotension prediction index
(HPI) based algorithm: In group H arterial cannula will be transduced to an HPI monitor and management will be done as per study protocol (Figure 1).
Firs
Sponsors
Post Graduate Institute of Meducal Education and Research, Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: a) Written informed consent b) Patient aged 18 years or more c) ASA 1, ASA 2 physical status d) Patients with aSAH undergoing clipping surgery including all SAH grades
Exclusion criteria
Exclusion criteria: a) Refuse to give consent for enrolling in the study b) Hemodynamically unstable patients on vasopressor or ionotropic support in preoperative period c) Patients with pre-existing morphological or interstitial renal pathology or chronic kidney disease, severe hepatic and cardiac dysfunction d) Pregnant patients e) Patient with uncontrolled DM, Congestive heart failure and active cardiac disease. F) Refuse to give consent for enrolling in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of the incidence of AKI (according to KDIGO AKI Staging) in both the groups Timepoint: At 1,2,3 and 7 days after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of incidence of intraoperative time weighted average mean arterial pressure (MAP) less than 65 mm Hg (TWA-AUT-65)Timepoint: on day of operation;Comparison of vasopressors and inotropic medication used in intraoperative period and during study periodTimepoint: from day of operation till end of 7 days;Comparison of value of serum creatinine postoperativelyTimepoint: At 24, 48, 72 hours and on postoperative day 7;Comparison of biomarker TIMP-2 and NGAL levels between the two study groupsTimepoint: On day of surgery before anesthetic induction and after 7 days postoperatively;Comparison of Perioperative fluid intake and blood losTimepoint: On day of operation;Incidence of SAH between good grade and poor grade SAHTimepoint: from day of operation till 7 days postoperatively;length of hospital stay and intensive care unit stayTimepoint: from day of operation until discharge of patient from hospital or death of patient in hospital (whichever earlier);Glasgow coma Extended (GOSE) scoreTimepoint: after 3 months from operation;modified Rankin score (mRS)Timepoint: At discharge from hospital | — |
Countries
India
Contacts
Public ContactShiv Lal Soni
POST GRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH, CHANDIGARH
Outcome results
None listed