Health Condition 1: J969- Respiratory failure, unspecified
Conditions
Interventions
Intervention1: Venous excess ultrasound (VExUS) assessment: Children will undergo ultrasound evaluation to calculate VExUS score and will be started on furosemide infusion in a protocolised manner de
Sponsors
NIL
Eligibility
Inclusion criteria
Inclusion criteria: Mechanically ventilated and hemodynamically stable without escalation of vasoactives and requirement of fluid bolus in the previous twelve hours
Exclusion criteria
Exclusion criteria: Right ventricular dysfunction Already on furosemide therapy Chronic kidney disease cirrhosis portal vein thrombosis Anticipated mechanical ventilation less than two days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day ventilation free daysTimepoint: Number of days free of invasive ventilation from day 0 of randomization till day 28 of randomization Death or discontinuation of care will be recorded as 0 | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative fluid overload percentageTimepoint: At the end of day 5 of PICU stay;Incidence of new/progressive AKITimepoint: Till 28 days after randomisation or till discharge from PICU or death, whichever is earlier;Oxygenation index until 72 hours after enrolmentTimepoint: Until 72 hours of enrolment;Organ dysfunction scores until 72 hours after enrolmentTimepoint: Until 72 hrs of enrolment | — |
Countries
India
Contacts
Public ContactKarthi Nallasamy
PGIMER: Post Graduate Institute of Medical Education and Research
Outcome results
None listed