Health Condition 1: H948- Other specified disorders of ear in diseases classified elsewhere
Conditions
Interventions
Intervention1: IVABRADINE: Ivabradine is administered orally at a dosage of 5mg, 2 hours before endotracheal intubation.It selectively inhibits the If current in the sinoatrial node, reducing heart ra
Sponsors
Government medical college
Eligibility
Inclusion criteria
Inclusion criteria: a.American Society of Anesthesiologists (ASA) –Physical Status grade I b.Patients with Mallampatti class I and II c.Patients with Normal ECG d.Patients Scheduled for elective non- cardiac surgery requiring endotracheal intubation.
Exclusion criteria
Exclusion criteria: a.Patients refusal or not consented to participate in the study. b.Patient with previous H/O Chest Pain/ Palpitations/Syncope c.Patient with H/o Respiratory Problems d.Patient with Hepatic or renal Problems e.Patient with Known allergies to Esmolol or Ivabradine f. Patient with History of cardiac conduction abnormalities. g.Patient with ECG abnormalities h.Patient with difficult airway i.Patient with Heart rate less than 60/minute and Systolic blood pressure less than 100mmHg j.Patient with total duration of laryngoscopy and intubation more than 20 seconds k.Patient with Mallampatti class III and IV Pregnant and lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean Heart rate, Mean Systolic blood pressure Mean diastolic blood pressureTimepoint: At base level, after study drug, after induction, after intubation, 1st minute, 3rd minute, 5th minute, 8th minute, 10th minute, 1st hour and 2nd hour | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse drug reactionTimepoint: after 12 hours of study drug | — |
Countries
India
Contacts
Public Contactsundharalingam senthilraj
government medical college, nalgonda.
Outcome results
None listed