Health Condition 1: J860- Pyothorax with fistula
Conditions
Interventions
Intervention1: Antibiotics: Intervention :
3 different groups with total antibiotic duration including oral and intravenous of 4 weeks versus 5 weeks versus 6 weeks.
Comparator agent : Clinical outc
Sponsors
Post Graduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Children less than 18 years of age with empyema. Empyema defined as pus in pleural cavity with clinical, laboratory and radiological features suggesting pneumonia or parapneumonic effusion
Exclusion criteria
Exclusion criteria: 1. Tubercular Empyema. 2. Empyema secondary to ruptured liver abscess. 3. Empyema secondary to ruptured hydatid cyst. 4. Empyema secondary to Mediastinitis. 5. Empyema secondary to Pancreatitis or Pleuropancreatic Fistula.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical worsening in terms of recurrence of fever/respiratory distress/readmission or worsening radiology by x ray or ultrasound requiring any intervention at stopping the antibiotics of prescribed duration that is attributable to empyema.Timepoint: time point at baseline, 4 weeks and 3 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| To document in the incidence of adverse drug effect warranting stoppage of antibiotics or admission during follow up. Marker of Pulmonary function 3 months after discharge viz Spirometry in children = 6 years old, 6-minute walk test in children 3-6 years old. CXR and USG at 3 months after discharge to document resolution of radiological features of empyema and/or residual pleural thickening Timepoint: time points different for different patients at 3 months of age | — |
Countries
India
Contacts
Public ContactRamakrishna M G
Post Graduate Institute of Medical Education and Research
Outcome results
None listed