Evaluating the effectiveness of hypochlorous acid in preventing surgical site infections: A randomised controlled trial in perforation peritonitis patients

Prospective randomised controlled study to evaluate the effectiveness of hypochlorous acid as a peritoneal lavage agent to prevent surgical site infection after exploratory laparotomy for perforation peritonitis - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/078118

Enrollment

144

Registered

2024-12-16

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K631- Perforation of intestine (nontraumatic)

Interventions

Intervention1: Peritoneal lavage with hypochlorous acid (50ppm): 2000 ml of 50ppm hypochlorous acid will be used for peritoneal lavage and 500 ml of 50ppm hypochlorous acid will used to irrigate wound

Eligibility

Inclusion criteria

Inclusion criteria: Dirty wound (class- IV)according to CDC classification. • Emergency surgery by midline or transverse laparotomy for perforation peritonitis . • Age = 18 years. • American society of anaesthesiologists (ASA) score = 3. • Ability to understand the nature and extent of the study and to give written informed consent.

Exclusion criteria

Exclusion criteria:

Design outcomes

Secondary

Measure	Time frame
To determine the safety profile of HOCI in peritoneal lavage.Timepoint: 30 days	—

Primary

Measure	Time frame
To compare the efficacy of HOCl ( Hypochlorous acid) versus normal saline in perforation peritonitis cases in view of superficial and deep incisional SSI.Timepoint: 30 days	—

Countries

India

Contacts

Public ContactDr Mayank Singh

Moti Lal Nehru Medical College, Prayagraj

Dr.mayanksingh78@gmail.com9005965779

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026