Health Condition 1: N049- Nephrotic syndrome with unspecified morphologic changes
Conditions
Interventions
Intervention1: Delaying steroid therapy in relapse of nephrotic syndrome: While the relapse in nephrotic syndrome is defined by 3 consecutive days of nephrotic range proteinuria, there is a dearth of
Sponsors
AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: Steroid sensitive nephrotic syndrome children aged 3 to 18 years with disease duration of more than 1 year and 3 consecutive days of nephrotic range proteinuria
Exclusion criteria
Exclusion criteria: Non adherence to urine protein diary maintenance, Development of edema within 3 days of onset of nephrotic range proteinuria, Severe infections mandating stress dose steroids, Steroid resistant nephrotic syndrome course in the past, Refusal of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In children with steroid sensitive nephrotic syndrome (SSNS) aged 3-18 years with 3 days of nephrotic range proteinuria, to estimate the proportion of children in whom steroid therapy is avoided by delaying the diagnosis of relapse till day 7 of asymptomatic nephrotic range proteinuria.Timepoint: day 7 | — |
Secondary
| Measure | Time frame |
|---|---|
| To study the time to remissionTimepoint: 6 weeks;To compare the proportion of children in whom steroid therapy is avoided between infrequent relapsing nephrotic syndrome and frequent relapsing nephrotic syndrome/ steroid dependent nephrotic syndromeTimepoint: 6 weeks;To compare the proportion of children in whom steroid therapy is avoided between proteinuria associated with infections and without infectionsTimepoint: 6 weeks;To estimate the proportion of children in need for relapse therapy within 6 weeks of onset of proteinuriaTimepoint: 6 weeks | — |
Countries
India
Contacts
Public ContactParaselli Saiteja
AIIMS, NEW DELHI
Outcome results
None listed