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A study to Compare targeted Fluid therapy with liberal Fluid Therapy in Adults Undergoing Major Emergency Surgery

Pulse pressure variation guided goal-directed fluid therapy versus liberal fluid therapy in adult patients undergoing major emergency surgery: A randomized controlled trial - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/12/078062
Enrollment
62
Registered
2024-12-12
Start date
Unknown
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: liberal fluid therapy: after induction of general anaesthesia patients will receive a balanced crystalloid solution (Plasmalyte) as per the Holliday–Segar 4-2-1 rule, along with the con

Sponsors

AIIMS Kalyani
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA (American Society of Anesthesiologists) physical status I-IV Major emergency surgery (including abdominal, thoracic, and pelvic surgery)- for example, surgery for Gastrointestinal perforation/ obstruction, obstructed hernia, appendicitis/Cholecystitis with sepsis/localised peritonitis, abdominal sepsis, Fournier/Maloney gangrene, necrotising fasciitis, penetrating/blunt trauma abdomen with solid organ injury or hollow viscera injury, Necrotising hemorrhagic pancreatitis, Thoracic empyema/ fungal infections, thoracic trauma, bronchopleural fistula grade II-IV air leak, Liver abscess, etc.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Sequential Organ Failure Assessment (SOFA) scoreTimepoint: preoperative postoperative- day1, day 3 and day 5—

Secondary

MeasureTime frame
serum lactate:Timepoint: preoperative, end of surgery or extubation and at first, second and fifth day;Serum albumin:Timepoint: preoperative, first, second and fifth day;C-reactive protein:Timepoint: preoperative, first, second fifth day;fluid balance, hypotension episode and vasopressor usageTimepoint: intraoperative period;Post-operative surgery-related complications, pulmonary, renal, cardiovascular and haematological complications and postoperative infection.Timepoint: postoperative period;All-cause mortality during the longest follow-up period. Timepoint: postoperative;Length of hospital stay (hospital LOS) in daysTimepoint: postoperative;Vasopressor or inotrope administration during the longest follow-up period to correct haemodynamic instabilityTimepoint: postoperative—

Countries

India

Contacts

Public ContactDr Roshan Andleeb

AIIMS Kalyani

roshan8978@gmail.com09045292647

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026