Health Condition 1: O- Medical and Surgical Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Intravenous injection of Labetalol 0.1 mg/kg: Intravenous injection of Labetalol 0.1 mg/kg over 10 minutes just before laryngoscopy and endotracheal intubation.
At 1 min
At 3 min
At 5 m
Sponsors
Smt.Bhikiben Kanjibhai Shah Medical Institute and Research Centre
Eligibility
Inclusion criteria
Inclusion criteria: Patients willing to sign written and informed consent. Male or Female patients between 18 to 65 years of age. Patients belonging to American Society of Anaesthesiologists(ASA) physical status I,II. Patients posted for elective surgeries under general anaesthesia.
Exclusion criteria
Exclusion criteria: Patients unwilling to participate in study. Patients with Body Mass Index more than 30 mg/m2. Patients with cardiovascular, cerebrovascular, hepatic and renal diseases. Bradycardia, HR less than 70/min. Arrhythmias. Psychiatric patients. Pregnancy and lactating women. Patients belonging to the American Society of Anaesthesiologists (ASA) III and above. Patients taking any type of medication for hypertension. Patients allergic to the study drugs. Patients with anticipated difficult airways. Patients with neuromuscular diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study hemodynamic and respiratory responses during endotracheal and laryngeal intubation.Timepoint: Preoperative After test drug administration During laryngoscopy and endotracheal intubation At 1 min At 3 min At 5 min At 7 min At 10 min | — |
Secondary
| Measure | Time frame |
|---|---|
| To study any intra operative complications like bradycardia, hypotension, arrhythmias.Timepoint: Hemodynamic parameters will be recorded every 2 minutes for 10 minutes after intubation. At 1 min At 3 min At 5 min At 7 min At 10 min | — |
Countries
India
Contacts
Public ContactDr Dinesh Chauhan
Smt.Bhikiben Kanjibhai Shah Medical Institute and Research Centre
Outcome results
None listed