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Single Dose Steroid Before Emergency Abdominal Surgery

Single Dose Steroid Before Emergency Laparotomy And Assessment of Inflammatory Response A randomized Controlled Trial - Nil

Status
Recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/12/078038
Enrollment
160
Registered
2024-12-12
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K271- Acute peptic ulcer, site unspecified, with perforation Health Condition 2: K650- Generalized (acute) peritonitis Health Condition 3: K565- Intestinal adhesions [bands] withobstruction (postinfection) Health Condition 4: K566- Other and unspecified intestinal obstruction Health Condition 5: S398- Other specified injuries of abdomen, lower back, pelvis and external genitals

Interventions

Intervention1: Single Dose Dexamethasone before emergency Laparotomy.: patients in this group will receive 1mg/kg Inj. Dexamethasone in iv drip immediately before undergoing emergency laparotomy. Con

Sponsors

Uttar Pradesh University of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients between 15 to 70 years having perforation peritonitis and intestinal obstruction or undergoing emergency laparotomy.

Exclusion criteria

Exclusion criteria: 1. Patients having Diabetes Mellitus 2. Patients having known auto-immune disorder. 3. Patients on prolonged steroid therapy. 4. Patients of HIV-AIDS 5. Patients not giving consent for the study.

Design outcomes

Primary

MeasureTime frame
APACHE-II SERUM CRP SERUM PROCALCITONINTimepoint: 1. At the Time of presentation. 2. 24 hours after the surgery or post-operative day-1 whichever is earlier.

Secondary

MeasureTime frame
ICU stay Total Hospital Stay Return of bowel sound Wound Infections Anastomotic Leak Need of Reoperation 30 days Mortality. Timepoint: total hospital stay ICU stay Return of bowel sound Wound Infection on Each post operative Day Anastomotic Leak Need of Re-operation will be assessed during the same admission. In follow up 3 Days , 7 Days & 30 Days after the Discharge

Countries

India

Contacts

Public ContactGAURAV MISHRA

Uttar Pradesh University of Medical Sciences, Saifai, Etawah

gauravmbbslko@gmail.com8874525139

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026