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Comparing the best combination of drugs which gives best pain relief after surgery

A comparison of postoperative analgesic efficacy between Dexmeditomidine with Levobupivacaine versus Dexmeditomidine with Ropivacaine in Ultrasound guided Transversus Abdominal block for total abdominal hysterectomy surgeries- A double blinded randomized controlled trial - Nil

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/12/078007
Enrollment
62
Registered
2024-12-12
Start date
Unknown
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Levobupivacaine Dexmedetomidine: O.25% Levobupivacaine 10 mL mixed with Dexmedetomidine 50 mcg given as TAP block post surgery DURATION - POD 0 - POD 2 Control Intervention1: Ropivacain

Sponsors

M Madhubalan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients between 18 to 60 years of both sexes Patients belonging to ASA CLASS 1 to ASA CLASS 2 posted for elective lower abdominal hysterectomy surgeries Weight from 50 to 80 kgs

Exclusion criteria

Exclusion criteria: Patient refusal for regional anaesthesia. Pregnancy and lactating female. Obese patients. Patience with ASA class three and four. Patient is allergic to local anaesthetics and Dexmeditomidine. Patient is having local site infection. Patients having any bleeding Coagulopathy disorders.

Design outcomes

Primary

MeasureTime frame
The duration of Analgesia in post-operative period between the two groups. It will be measure with parameters such as VAS score , BLOOD PRESSUE , PULSE RATE .Timepoint: Post operative day 0 to Post operative day 02

Secondary

MeasureTime frame
To monitor heart rate, BLOOD PRESSURE, SPO2 , VAS SCORE from the time of TAP block to the time of break through pain. To monitor for complications, if any, from the time of tap block to the time of breakthrough painTimepoint: Postoperative period ( POD 0 to POD 02 ) - From the End of Surgery to the period of Patient getting medication for pain .

Countries

India

Contacts

Public ContactMadhubalan Manivannan

Shri Sathya Sai Medical College and Research Institute

anusha14scorpio@gmail.com9003738506

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026