A study to compare the efficacy of Topical Timolol based dressing versus Normal Saline dressing in the healing of chronic non-healing wounds

Comparison of topical timolol versus conventional therapy for healing of chronic non-healing wounds- a randomized control trial - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/078006

Enrollment

Registered

2024-12-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: 0.5% Topical Timolol solution with 0.9% Normal saline: To each patient, one drop of 0.5% Timolol will be instilled every 2 cmÂ² of wound edge in addition to Normal Saline based dressing

Eligibility

Inclusion criteria

Inclusion criteria: Patients above 18 years of age with chronic ulcers of more than 4 weeks duration and less than 1 year duration 2. Surface area between 0.5 cm2 and 100 cm2 (measured using the smartphone-based app -imito measure11). Ulcers with the largest surface area and longest duration meet the criteria in case of multiple ulcers

Exclusion criteria

Exclusion criteria: 1.Pressure ulcers 2. Patients with history of bradycardia (heart rate less than 60) 3. Patients with medically documented history of hypotension/orthostatic hypotension and/or symptomatic hypotension (systolic blood pressure below 90 and diastolic blood pressure less than 60). 4. Patients currently taking asthma or COPD medications 5. Patients having palpitations, syncope, dyspnea, and/or angina at rest 6. Ulcers with signs of active infection such as cellulitis, purulent exudate, osteomyelitis or exposed bones, tendon and fascia 7. Patients with known immunodeficiency 8. Patients with known chronic kidney or liver disease 9. Patients who received prior radiation or chemotherapy 10. Female patients who are pregnant.

Design outcomes

Primary

Measure	Time frame
To determine the effect of topical timolol on wound healing in chronic non-healing ulcers measured in terms of percentage reduction in wound surface area over an 8 week periodTimepoint: At the time of initial presentation-day 1 At the end of 2,4,6 and 8 weeks	—

Secondary

Measure	Time frame
To assess the pathological strength of granulation.Timepoint: Over an 8 week period;To assess the microbiological profile of the ulcer.Timepoint: Over an 8 week period	—

Countries

India

Contacts

Public ContactDr. Dhinesh S

JIPMER

drbalak@gmail.com9443617089

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026