Effect of different positive end expiratory pressures on lung strain in acute respiratory distress syndrome patients: randomized study

Comparison of the lung strain with incremental positive end expiratory pressure (PEEP) and decremental positive end expiratory pressure (PEEP) recruitment maneuver in acute respiratory distress syndrome (ARDS) patients: prospective observational trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/077976

Enrollment

Registered

2024-12-11

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J80- Acute respiratory distress syndrome

Interventions

Intervention1: Group I: Application of Incremental PEEP on day 1 and Decremental PEEP on day 2 Intervention2: Group D: Application of Decremental PEEP on day 1 and Incremental PEEP on day 2 Control In

Eligibility

Inclusion criteria

Inclusion criteria: mechanically ventilated patients diagnosed with mild to moderate ARDS according to berlins definition

Exclusion criteria

Exclusion criteria: patient/attender refusal pregnancy large pleural effusion pneumothorax emphysema broncho-pleural fistula inter-costal draining tube in-situ increased intracranial pressure right heart failure with pulmonary hypertension hemodynamic instability

Design outcomes

Primary

Measure	Time frame
changes in lung strain changes in end expiratory lung volume (EELV)Timepoint: At each PEEP level on day 1 and day2	—

Secondary

Measure	Time frame
effect on oxygenation effect on compliance of the lung determining optimal PEEPTimepoint: baseline, post-recruitment on day 1 & day 2	—

Countries

India

Contacts

Public ContactEMANI ROJA

Nizams Institute of Medical Sciences

narmadapadhy1@gmail.com7036004706

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026