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evaluation of saliva and blood levels of specific biomolecules in patients with gum disease and high blood sugar levels

Comparative evaluation of salivary and serum Interleukin-38 levels in periodontitis subjects with and without type 2 diabetes mellitus following non-surgical periodontal therapy - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/12/077958
Enrollment
84
Registered
2024-12-11
Start date
Unknown
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Non-surgical periodontal therapy (NSPT): After baseline sample collection, root surface debridement (NSPT) will be done and after 4 weeks of RSD, again the samples will be collected fro

Sponsors

Dr Devapriya Appukuttan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.systemically healthy patients 2.Patients with stage III grade C periodontitis 3.Patients with type II diabetes mellitus

Exclusion criteria

Exclusion criteria: Exclusion criteria: 1.Patients under Immunosuppressants and or antibiotics and or anti-inflammatory medications. 2.Pregnant or lactating mothers  3.Current and past smokers  4.Previous history of periodontal or orthodontic therapy. 5.Patients receiving iron replacement therapy for anemia.  6.Patients with Uncontrolled diabetes mellitus 7. Patients with a history of any other systemic disease other than type 2 diabetes mellitus 8. Subjects not willing to participate and not willing to give consent.

Design outcomes

Primary

MeasureTime frame
1. To estimate the levels of IL-38 in the saliva and serum of periodontally healthy, periodontitis patients with and without T2DM at baseline before NSPT. 2. To estimate the levels of IL-38 in the saliva and serum of periodontitis patients with and without T2DM post NSPT. 3. To estimate the changes in the saliva and serum level of IL-38 pre and post NSPT in periodontitis patients with and without T2DMTimepoint: At baseline and after NSPT—

Secondary

MeasureTime frame
1. To correlate the saliva and serum levels of IL-38 with the clinical parameters both at baseline and after NSPT in periodontitis patients with and without T2DM. 2. To correlate between the serum and saliva levels of IL-38 in periodontally healthy, periodontitis patients with and without T2DM 3. ROC analysis to evaluate the utility of IL-38 as a biomarker to discriminate between periodontal health and disease in the presence and absence of T2DM.Timepoint: At baseline and after NSPT—

Countries

India

Contacts

Public ContactDR D J Victor

SRM Dental College

dr.djvictor@gmail.com9841009952

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026