Health Condition 1: O85- Puerperal sepsis
Conditions
Interventions
Intervention1: group2: Drug regime: Injection Ceftriaxone 1gm IV once only + injection Azithromycin 500 mg IV in 250 ml of NS within 1 hour once only 30-60 minutes before incision.
A repeat dose of a
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Undergoing c-section No History of allergy for ceftriaxone and azithromycin
Exclusion criteria
Exclusion criteria: Use of antibiotics in the last 7 days of c-section. Known allergy to any of the study antibiotics. Ruptured membranes for more than 24 h or at place other than the hospital Evidence of infection or fever, preoperatively or during surgery Women with any comorbidity, e.g., overt DM, TB, any heart disease, or any chronic illness. Preop hemoglobin less than 7g/dl
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the incidence of SSI between prophylactic combination of ceftriaxone and azithromycin and prophylactic combination ceftriaxone and cefuroxime in Indian pregnant women undergoing c-sectionTimepoint: 7 days, 14 days, 30 days, 42 days | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare severity, time to develop surgical site infection between two groups. 2. To compare severity of SSI between 2 groups. 3. To compare the incidence of the neonatal sepsis between two groups. 4. To compare incidence, time to develop UTI between two groups. 5. To compare incidence, time to develop Endometritis between two groups. Timepoint: 7 days, 14 days, 30 days, 42 days | — |
Countries
India
Contacts
Public ContactPURNIMA SAGAR
AIIMS PATNA
Outcome results
None listed