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Comparison of cardiovascular biomarker in gingival fluid in diabetic and non-diabetic patients with gingival disease

EFFECT OF PERIODONTAL INTERVENTION ON THE LEVELS OF N TERMINAL PRO BRAIN NATRIURETIC PEPTIDE IN GINGIVAL CREVICULAR FLUID IN DIABETIC AND NON-DIABETIC PATIENTS WITH PERIODONTITIS - Effect of periodontal intervention on the levels of N Terminal Pro Brain Natriuretic Peptide in gingival crevicular fluid in diabetic and non-diabetic patients with Periodontitis

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/12/077932
Enrollment
42
Registered
2024-12-10
Start date
Unknown
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: scaling and root planing and collection of gingival crevicular fluid: collection of gingival crevicular fluid before scaling and root planing and 3 months post scaling and root planing

Sponsors

JSS Dental College and Hospital Mysuru
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients within the age 35-50 years 2. Duration of diabetic more than one year 3. Subjects with = 18 completely erupted teeth 4. Subjects with presence of bleeding on probing 5. Probing pocket depth = 5mm 6. Clinical attachment level = 6mm

Exclusion criteria

Exclusion criteria: 1. No evidence of systemic diseases other than diabetes as a risk factor for periodontitis 2. Atherosclerotic vascular disease (i.e., CVD, stroke and peripheral artery disease) 3. Arthritis/osteoporosis 4. History of periodontal intervention within the last 6 months 5. Anti-inflammatory and non-steroidal anti-inflammatory therapy within 3 months prior to periodontal assessment 6. Pregnancy 7. Lactation

Design outcomes

Primary

MeasureTime frame
To evaluate the association between diabetes mellitus and cardiovascular disease as potential risk factors for periodontal diseaseTimepoint: 3 months

Secondary

MeasureTime frame
To assess the clinical periodontal parameters, plaque index, gingival index, clinical attachment loss & probing pocket depth before & after scaling & root planingTimepoint: 3 months

Countries

India

Contacts

Public ContactDr Dakshina J

JSS Dental College and Hospital, Mysuru

dr.anitha.den@gmail.com09945376455

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026