Health Condition 1: A00-B99- Certain infectious and parasitic diseases
Conditions
Interventions
Intervention1: Early administration of oral fludrocortisone in septic shock patients.: Adult patients with septic shock within 24 hours of norepinephrine initiation, oral fludrocortisone 50 micrograms
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients with septic shock within 24 hours of initiation of norepinephrine.
Exclusion criteria
Exclusion criteria: Age less than 18 years and more than 75 years. Pregnant and lactating patients, Patients with known history of chronic kidney disease, chronic liver disease, congestive heart failure, patients with hypernatremia and hypokalemia, high vasopressor requirement are excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effect of early administration of fludrocortisone and vasopressor-free days in early septic shock within the first 14 days of recruitment.Timepoint: At baseline and within first 14 days of recruitment | — |
Secondary
| Measure | Time frame |
|---|---|
| ? Duration of shock (Total days on vasopressor) ? Total daily vasopressors dose from days 1to14. ? Change in SOFA in the first seven days of enrolment. ? Ventilator-free days at day 30 after enrolment. ? ICU-free days at day 30 after enrolment. ? Mortality in the first 30 days of recruitment. ? Incidence of hypernatremia ? Incidence of hypokalaemia ? Incidence of hyperglycaemia ? Incidence of RRT ? Change in CRP, IL 6 during the first seven days after recruitment. ? Hospital-acquired infections. Timepoint: At end of 30 days from recruitment. | — |
Countries
India
Contacts
Public ContactViswanath S
AIIMS, New Delhi
Outcome results
None listed