Topical Tranexamic Acid in reduction of seroma after Modified radical mastectomy.

Effect of topical tranexamic acid in reducing axillary drain output post modified radical mastectomy Surgery - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/077847

Enrollment

Registered

2024-12-09

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C509- Malignant neoplasm of breast of unspecified site Health Condition 2: O- Medical and Surgical Health Condition 3: C509- Malignant neoplasm of breast of unspecified site Health Condition 4: C509- Malignant neoplasm of breast of unspecified site

Interventions

Intervention1: Local application of Tranexamic acid: Single time application of Local Tranexamic acid in axillary bed after skin closure after modified radical mastectomy in a strength of 500 mg dilut

Eligibility

Inclusion criteria

Inclusion criteria: All patients above 18 years of age diagnosed with breast carcinoma undergoing modified radical mastectomy

Exclusion criteria

Exclusion criteria: Pregnancy Patients with known thromboembolic disease Patients not giving consent or not understanding the nature of the study

Design outcomes

Primary

Measure	Time frame
to study the effects of topical tranexamic acid application on axillary drain output post modified radical mastectomyTimepoint: Daily drain output will be measured. The drain will be removed on the day when the daily drain output recorded will be less than 30ml on two consecutive days.	—

Secondary

Measure	Time frame
Incidence of seroma formation after drain removal at the end of three months Incidence of surgical site infection at day 30 after MRM Day of conversion of nature of drain fluid from sanguineous to serous.Timepoint: Incidence of surgical site infection at the end of 30 days. Incidence of seroma formation at the end of three months. Day of Day of conversion of nature of drain fluid from sanguineous to serous.	—

Measure

Time frame

Incidence of seroma formation after drain removal at the end of three months Incidence of surgical site infection at day 30 after MRM Day of conversion of nature of drain fluid from sanguineous to serous.Timepoint: Incidence of surgical site infection at the end of 30 days. Incidence of seroma formation at the end of three months. Day of Day of conversion of nature of drain fluid from sanguineous to serous.

—

Countries

India

Contacts

Public ContactPradeep Kumar Singh

All India Institute of Medical Sciences, Bhubaneswar

iaakarsh1998@gmail.com9543243166

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026