Health Condition 1: K135- Oral submucous fibrosis
Conditions
Interventions
Intervention1: group 1 healthy patients with no habit and without any systemic disease Group 2 Healthy Patients with habit and without systemic Disease group 3 oral submucous Fibrosis Patients: After
Sponsors
Dr kavita wadde
Eligibility
Inclusion criteria
Inclusion criteria: Patients of the age group 25-55 years were included in the study. 2. Patients consuming gutka, areca nut chewing habit. 3. Healthy patients without habit or any disease, healthy patients with habit without any disease. 4. Patients with clinically diagnosed and histopathological confirmed Oral Submucous Fibrosis. 5. Patients who have not received any prior treatment for Oral Submucous Fibrosis. 6. Patients without any TMJ disorders or any history of trauma.
Exclusion criteria
Exclusion criteria: 1. Patients with systemic diseasesto alterserum LDH levelssuch as Myocardial Infarction, Liver disease, Pulmonary disorders, Renal disorders and Muscle dystrophy. 2. Immunocompromised patients 3. Patients who have a habit of smoking cigarettes. 4. Patients under corticosteroid therapy 5. Patientsreceiving iron supplements. 6. Patients with other mucosal lesions other than OSMF. 7. Any Oral and Maxillofacial infections and any salivary disorders. 8. Patients who received any treatment for Oral Cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the significant role of Salivary LDH, MMP-9 and Ferritin in screening and early detection of Oral Submucous Fibrosis and also evaluate the expression of PD-1 and PD-L1 in Oral Submucous Fibrosis. Timepoint: Assessment will be done at the baseline at the time of collection of samples | — |
Secondary
| Measure | Time frame |
|---|---|
| It can be used as screening mass population in precancerous conditionsTimepoint: assessment will be done at baseline at the time sample collection | — |
Countries
India
Contacts
Public ContactDr kavita wadde
Government Dental College and Hospital Mumbai
Outcome results
None listed