A clinical trial to study the effects and safety of two creams, calcitriol and adapalene, in patients with mild and moderate acne.

Comparative Efficacy of Topical Calcitriol versus Topical Adapalene in the Treatment of Mild and Moderate Acne: A Randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/077823

Enrollment

100

Registered

2024-12-09

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L700- Acne vulgaris

Interventions

Intervention1: 0.0003% Calcitriol ointment: Once daily application for 3 months Control Intervention1: 0.1% Adapalene gel: Once daily application for 3 months

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18 years or older, of either gender and any racial/ethnic group with mild (GAGS score 1-18) and moderate acne (GAGS score 19-30) according to Global Acne Grading System (GAGS) 2. Subjects must understand and sign the informed consent before participation

Exclusion criteria

Exclusion criteria: 1. Severe acne (GAGS score more than 30) 2. Pregnancy or breastfeeding 3. History of hypersensitivity or allergic reaction to study medications 4. On topical treatment (4 weeks before participation) or systemic treatment (3 months before enrolment) for acne 5. Any concomitant dermatological or systemic illness 6. Patients who are unable to follow up

Design outcomes

Primary

Measure	Time frame
1. Reduction in total lesion count (Total, Inflammatory and Non-inflammatory) 2. Reduction in acne severity and global acne grading scoreTimepoint: 0, 4 weeks, 8 weeks and 12 weeks	—

Secondary

Measure	Time frame
Safety profile of both the topicals graded on 4 point scaleTimepoint: 0, 4 weeks, 8 weeks and 12 weeks	—

Countries

India

Contacts

Public ContactAditi Shende

Symbiosis Medical College for Women and SUHRC

hod.dermatology@smcw.siu.edu.in9823154022

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026