Health Condition 1: G30- Alzheimers disease
Conditions
Interventions
None listed
Sponsors
Ministry of AYUSH, Government of India
Eligibility
Inclusion criteria
Inclusion criteria: 1. Montreal Cognitive Assessment (MoCA) score of 13â??23, mild to moderate severity (DSM-5). 2. Patients of age group 50-80 years of either sex. 3. Educational level above 7th standard with a family member or informal career. 4. Right handedness.
Exclusion criteria
Exclusion criteria: 1. Patients with severe dementia, known neuropsychiatric conditions, dependence of any psychoactive substances and evidences of malignancy. 2. Patients with uncontrolled endocrinological disturbances, hypertension or other systemic illness. 3. Patients with other neurodegenerative disorders like Lewy body dementia, Fronto-temporal Dementia. 4. Patients with uncontrolled Type 2 Diabetes mellitus 5. Patients on β-blockers, thiazide diuretics, corticosteroids, HRT. 6. Patients with Uncontrolled Blood pressure. 7. Patients with concurrent Hepatic Dysfunction 8. Patients with Renal Dysfunction Patients with severe Pulmonary Dysfunction 9. Patients with evidence of malignancy 10. Patients suffering from major systemic illness necessitating long-term drug treatment. 11. Patients who have completed participation in any other clinical trial during the past six (06) months. 12. Left-handedness 13. Education level is less than 8th grade.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in NIMHANS Neuropsychological Battery for Elderly (NIMHANS NPBE) and Clinical Dementia Rating Scale (CDRS)Timepoint: Baseline and 90th day | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Changes in functional Magnetic Resonance Imaging (fMRI) 2. Changes in Herat Rate Variability (HRV). 3. Changes in Neuro gut biomarkers 4. Changes in Telomere length Timepoint: Baseline and 90th day | — |
Countries
India
Contacts
Public ContactDr Kishore Kumar R
National Institute of Mental Health and Neurosciences
Outcome results
None listed