Health Condition 1: I998- Other disorder of circulatory system
Conditions
Interventions
Intervention1: METHYLENE BLUE: In septic shock patients, when Norepinephrine dose reached 0.20 mcg/kg/min, Vasopressin is initiated at 0.03IU/min, methylene blue is administered after test dose along
Sponsors
DR RISHWANTH RAJA P M
Eligibility
Inclusion criteria
Inclusion criteria: 1)Age greater than 18 years, 2)Highly suspected or confirmed infection 3)Norepinephrine dose greater than 0.2mcg/kg/min to maintain MAP greater than 65 mmHg 4)Less than 6 hrs of starting noradrenaline
Exclusion criteria
Exclusion criteria: 1)Pregnancy 2)Chronic kidney disease 3)Concurrent hemorrhagic, obstructive, cardiogenic, hypovolemic shock, 4)Greater than 24 hours of septic shock, History of glucose-6-phosphate dehydrogenase deficiency, 5)Allergy to methylene blue 6)Drug interactions: Phenothiazines, selective serotonin re-uptake inhibitors, Dapsone 7)Refusal of the patient or decision maker to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess whether early adjunctive Methylene blue can reduce time to vasopressor discontinuation in patients with septic shockTimepoint: 7 days 14 days 21days | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the effects of continuous infusion of methylene blue on cardiac & renal SOFA scores, serum lactate levelsTimepoint: 24 hours 48 hours 72 hours | — |
Countries
India
Contacts
Public ContactDr Rishwanth Raja P M
Sri Ramachandra Institute of Higher Education and Research
Outcome results
None listed