Health Condition 1: F112- Opioid dependence
Conditions
Interventions
Intervention1: ARM 1.
Active Injection + Placebo Sublingual: The Intervention involves a one-time administration of Intravenous 2 mg buprenorphine/4 ml as bolus in visible upper limb vein + 2 placebo
Sponsors
Anjali Yadav
Eligibility
Inclusion criteria
Inclusion criteria: As per ICD 11 criteria, Patients Diagnosed with Opioid Dependence will be included in the study. The patient should be admitted to NDDTC for the treatment of opioid dependence. Patients should have: 1. History of opioid use for more than 2 years. 2. History of injecting opioid use for at least one year with the last injection within last three months.
Exclusion criteria
Exclusion criteria: The following patients will be excluded from the study: 1. Patients with current dependence on substances other than opioids (except nicotine) 2. Patients with the use of any psychoactive substance (except opioids, nicotine, medications except CNS depressants) within the last 72 hours 3. Patients with any active general medical illnesses or neurological disorder, psychiatric illnesses or disability hampering communication / informed consent process (clinically assessed)/ Experiment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Plasma Levels 2. Subjective effects scalesTimepoint: 7 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparing Plasma levels of Buprenorphine with subjective effectsTimepoint: 3 hours | — |
Countries
India
Contacts
Public ContactAnjali Yadav
National Drug Dependence Treatment Centre(NDDTC), All India Institute of Medical Sciences, New Delhi
Outcome results
None listed