Health Condition 1: J708- Respiratory conditions due to other specified external agents
Conditions
Interventions
Intervention1: Prednisolone,Itraconazole: Tablet Prednisolone(1 month)–Capsule Itraconazole(4month)
(The dosage of prednisolone Would be 0.5 mg/kg for the first week, followed by 0.25 mg/kg for the s
Sponsors
Jisha G Panicker
Eligibility
Inclusion criteria
Inclusion criteria: Treatment-naive acute-stage ABPA and included them if they met the following criteria: 1.Aspergillus fumigatus-specific IgE levels >0.35 kUA/L or immediate cutaneous hyperreactivity on Aspergillus skin test. 2.Elevated serum total IgE levels >500 IU/ML and two of the following a) Presence of precipitating antibodies (or IgG >27 mg/L) against Aspergillus fumigatus in serum. b)Peripheral blood eosinophilia >500 µL, c) Chest radiographic and/or computed tomography (CT) abnormalities consistent with Allergic Bronchopulmonary aspergillosis.
Exclusion criteria
Exclusion criteria: 1.Not giving consent for the study enrolment. 2.intake of systemic glucocorticoids or triazoles for morethan 3 weeks in the preceding 6 months 3.concomitant use of medications, including voriconazole, inhaled amphotericin B,omalizumab or other biological agents 4.uncontrolled diabetes mellitus 5.chronic renal failure, 6.chronic liver failure 7.patients on immunosuppressive drugs 8.Pregnant females.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the remission rates at 3 and 6 months following the completion of a 4 month treatment course in each group.Timepoint: baseline, 6 weeks, 16 weeks, 28 weeks, 40 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare treatment related adverse effects in both groups. Timepoint: 6 weeks, 4 months after starting treatment;To compare clinical response rates at 6 weeks and 4 months on both groupsTimepoint: 6weeks, 4months after starting treatment | — |
Countries
India
Contacts
Public ContactJisha G Panicker
AIIMS Patna
Outcome results
None listed