A clinical trial to compare mental and motor recovery after intravenouos dexmedetomidine or intravenous low dose ketamine in patients undergoing general anaesthesia

Comparison of psychomotor recovery of intravenous dexmedetomidine bolus with intravenous subanaesthetic ketamine in patients undergoing general anaesthesia: A prospective randomized double blind study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/077710

Enrollment

Registered

2024-12-05

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Intravenous dexmedetomdine: preoperatively before induction of anaesthesia intravenous dexmedetomidine 1mcg/kg intravenously given over 15 minutes Control Intervention1: intravenous su

Eligibility

Inclusion criteria

Inclusion criteria: 1.age between 18-65 years 2.ASAPS I, II III 30. Patients scheduled for surgeries under general anaesthesia. 3. Minimum duration of surgery lasting more than 180 minutes.

Exclusion criteria

Exclusion criteria: 1. Patients unwilling to participate in the study. 2. Patients who are unable to give informed consent. 3. Patients with known history of psychiatric illness, chronic drug or alcohol abuse. 4. Patients with known hypersensitivity to drugs used. 5. Pregnant and lactating women. 6. BMI>30kg/m 2 . 7. Patients on concurrent sedative medications. 8. Patients who are unable to attempt or perform the DSST test.

Design outcomes

Primary

Measure	Time frame
to compare the psychomotor recovery profile of patients receiving either IV dexmedetomidine bolus (Group D) or subanaesthetic ketamine bolus (Group K) by Digit Symbol Substitution Test (DSST) postoperatively at 15,30,60,90,120 minutes post extubationTimepoint: to compare the psychomotor recovery profile of patients receiving either IV dexmedetomidine bolus (Group D) or subanaesthetic ketamine bolus (Group K) by Digit Symbol Substitution Test (DSST) postoperatively at 15,30,60,90,120 minutes post extubation	—

Measure

Time frame

to compare the psychomotor recovery profile of patients receiving either IV dexmedetomidine bolus (Group D) or subanaesthetic ketamine bolus (Group K) by Digit Symbol Substitution Test (DSST) postoperatively at 15,30,60,90,120 minutes post extubationTimepoint: to compare the psychomotor recovery profile of patients receiving either IV dexmedetomidine bolus (Group D) or subanaesthetic ketamine bolus (Group K) by Digit Symbol Substitution Test (DSST) postoperatively at 15,30,60,90,120 minutes post extubation

—

Secondary

Measure	Time frame
additional boluses of fentanyl givenTimepoint: intraoperatively;propofol boluses givenTimepoint: intraoperatively;to Compare Postoperative sedationTimepoint: 15,30,60,90,120 minutes postoperatively;time to first request of analgesiaTimepoint: postoperatively;hemodynamic changesTimepoint: post induction immediately	—

Countries

India

Contacts

Public ContactDr N Hemanth

Sri venkateswara institute of medical sciences

hemanthn1973@gmail.com9440285634

Outcome results