Health Condition 1: R99- Ill-defined and unknown cause of mortality Health Condition 2: B96- Other bacterial agents as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Infusion neostigmine at dose of 0.2mg/hour for 120 hours on septic shock patients in test group: Infusion neostigmine will be given to septic shock patients at 0.2mg/hour for 120 hours
Sponsors
All India Institute of Medical Sciences Jodhpur
Eligibility
Inclusion criteria
Inclusion criteria: Patients having clinical features suggestive of septic shock (requiring vasopressor support to maintain mean arterial pressure greater than 65mmHg)
Exclusion criteria
Exclusion criteria: 1. Known absolute contraindications against cholinesterase inhibitors such as myotonic dystrophy,depolarisation block by depolarizing muscle relaxant, intoxication by irreversibly acting cholinesterase inhibitors,closed cerebral trauma 2. Known relative contraindications against cholinesterase inhibitors for example bronchial asthma,bradycardia,A-V conduction disturbances 3. Pregnant and lactating women 4. Having undergone solid organ transplantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the duration of recovery from septic shock in patients treated with standard therapy and those treated with Neostigmine adjuctive therapyTimepoint: Follow up of 28 days will be done for 28 days mortality and shock reversal, other parameters will be assessed for 5 days | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the change in SOFA score after 120 hrs of neostigmine adjunctive therapy. To compare APACHE II score after 120 hrs of neostigmine adjunctive therapy. Timepoint: 120 hours after starting the neostigmine infusion. | — |
Countries
India
Contacts
Public ContactNikhil Kothari
All India Institue of Medical Sciences (AIIMS), Jodhpur
Outcome results
None listed