This study is conducted to compare the differences between calcium hydroxide, triple antibiotic paste and triple antibiotic paste with nanoparticles used during root canal treatment.

Comparative Microbiological Evaluation of Calcium Hydroxide, Triple Antibiotic Paste and Triple Antibiotic Paste with Nano Particles as Intracanal Medicaments in Symptomatic Apical Periodontitis : A Randomized Clinical Study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/12/077596

Enrollment

Registered

2024-12-03

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin

Interventions

Intervention1: Calcium hydroxide: Calcium hydroxide will be placed after cleaning and shaping of the root canal. then it will be evaluated microbiologically on 14th day and 28th day. Intervention2: Tr

Eligibility

Inclusion criteria

Inclusion criteria: Patient with chronic irreversible pulpitis with symptomatic apical periodontitis indicated for endodontic treatment. Age group 18 and 50. PAI score less than or equal to 3. Mandibular premolars with single root and single canal. patient who is having no necessity of antibiotics in the past 3 months. the tooth which showed no response to thermal and electric pulp tests. patients having no significant systemic conditions. patients who is ready to give written informed consent.

Exclusion criteria

Exclusion criteria: Fractured tooth Root resorption Retreatment cases Calcified canals Tooth with Endo periodontitis lesions Extra oral sinus tracts

Design outcomes

Primary

Measure	Time frame
To evaluate and compare the antimicrobial efficacy of calcium hydroxide, Triple antibiotic paste and triple antibiotic paste with nanoparticles (chitosan)Timepoint: on 14th and 28th day	—

Secondary

Measure	Time frame
PainTimepoint: on 24 hours, 72 hours and 7 days	—

Countries

India

Contacts

Public ContactDr Akshay Gaikwad

M A Rangoonwala dental college and hospital, pune

drvivekhegde@gmail.com9822055434

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026