Health Condition 1: F079- Unspecified personality and behavioral disorder due to known physiological condition
Conditions
Interventions
Intervention1: NA: NA
Control Intervention1: NA: NA
Sponsors
Dr. Puneet Khanna
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients age above 60 years. 2. Undergoing orthopaedics surgery under general anaesthesia. 3. Can give informed consent themselves. 4. There is no minimum cognitive performance required to participate.
Exclusion criteria
Exclusion criteria: 1. Patients with a history suggestive of dementia (either listed in the medical record or reported by the patient) or any neurological disorder. 2. History of alcohol abuse, chronic opioid or other substance abuse 3. History of cerebral surgeries, and stroke. 4. History suggestive of psychiatric disease like schizophrenia, dementia, anxiety, or other disorders affecting cognition, mental dysfunction 5. Prescription of central nervous system–active medication (eg: antidepressants, antipsychotics, sedatives)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the association between pre-operative telomere length in peripheral blood leukocytes and incidence of post operative delirium oxidative stress in elderly population undergoing major orthopedics surgeryTimepoint: 24 hours pre and postoperative | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To determine the association of blood glucose levels and serum electrolytes to postoperative delirium and cognitive functioning in elderly population undergoing major orthopedics surgery. 2. To study the association of oxidative stress and plasma, brain derived nerve growth factor (BDNF) levels with change in telomere length in peripheral blood leukocytes.Timepoint: 24 hours pre and postoperative | — |
Countries
India
Contacts
Public ContactDr Puneet Khanna
AIIMS, New Delhi
Outcome results
None listed